Bruker introduced four important new preclinical imaging systems at the World Molecular Imaging Congress 2015 in Honolulu, Hawaii. The new products will deliver improved performance to routine imaging and open new horizons for advanced research applications, allowing complex multimodal research projects to become a reality. Researchers will gain a more complete picture and deeper insights into the causes and effects of disease, accelerating the translation of results for human patients.
Next-Generation Albira™ Si PET/SPECT/CT System
Sharing the new PET detector technology from the PET/MR combined system, the new Albira Si delivers full field of view accuracy and sub-millimeter resolution across an axial FOV of more than 70 mm for the first time. Combined with exceptional count rate performance and better than 9% sensitivity, Albira Si provides the ideal solution for dynamic and gated PET in-vivo studies.
The Albira Si still offers all of the benefits of full multimodal integration with SPECT and CT imaging in a single footprint. CT modality provides anatomical reference and attenuation correction for functional PET and SPECT imaging. A wide range of animal beds and monitoring and gating accessories are also available. Additionally, the system is fully compatible with Bruker’s Multimodal Animal Beds for cross-platform MR, CT, and optical imaging. A new generation of powerful, easy to use software, developed by and for both full body and organ specific research needs, is opening new options for more effective acquisition, processing and evaluation of images and quantitative data.
Professor Jose Benlloch, Director of the Institute for Instrumentation in Molecular Imaging (I3M) at the Polytechnical University of Valencia in Spain, explained: “The new Silicon PM detector technology has major advantages in providing better PET position, energy and timing resolution, and it is compatible with MRI. An additional significant benefit of our unique, continuous crystals technology pioneered at I3M, is the greatly enhanced DOI detection for highest resolution across the entire field of view, which is very beneficial for virtually all preclinical PET applications.”
New BioSpec® 3T Preclinical MRI System with Superior Cryogen-free Magnet
With the BioSpec 3T Bruker is extending its range of multi-purpose MRI/MRS research systems, bridging the gap between morphological reference imaging at 1T and high-end research level MRI imaging at high field. New superior liquid cryogen free magnet technology overcomes the challenges associated with conventional cryogen free technology with respect to extended field hold times during power outages or cold water failures by a factor of 10 and more, of up to 4 hours.
The BioSpec 3T features an 18 cm magnet bore, and is upgradable to PET/MRI. Adding Bruker’s proprietary MRI CyroProbe™ for mice and rats, MRI sensitivity and spatial resolution can optionally be increased to be comparable to conventional 7T MRI. The new ParaVision 6 software features validated in vivo protocols, and an easy-to-use preclinical user interface that unifies workflows across different modalities, with facile multi-modality image fusion.
Next-Generation PET/MRI System
The latest breakthrough in Albira Si PET detector technology, together with the proven superior soft tissue contrast of translational field strength of the BioSpec 3T MRI, are now available in one compact instrument. A broad spectrum of application fields, such as: oncology, functional and anatomical neuroimaging, orthopedics, cardiac imaging and stroke models, will benefit from combining two powerful modalities in one system with a focus of ease-of-use, reliability and uncompromised performance
Significant hardware and software innovations are introduced with the new system. A motorized animal transport system enables complex PET/MR research protocols and eliminates the need for image co-registration.. Moving table acquisitions for MR based PET attenuation correction and image fusion as well as whole body scans are supported. Built-in Multimodal Animal Beds are fully compatible with other Bruker molecular imaging devices. Importantly, an improved ParaVision® software package automates the dual-modality workflow, data handling and image fusion.
New, High-Sensitivity Xtreme II Optical Molecular Imaging System
The integration of a new CCD camera into the proven architecture of the award winning Xtreme brings a new level of sensitivity, speed, and versatility to non-invasive procedures. The result is greater freedom for researchers to discover important biological mechanisms in disease, important for treatment and monitoring. By cooling the camera to less than -90° C, and using exceptionally low read noise electronics, new levels performance during extremely low-light applications, such as bioluminescence and Cerenkov imaging, are achieved. This level of performance has not been previously available.
Versatility is maintained with five imaging modalities provided as standard within the Xtreme II, allowing for co-registration of molecular events with access to bioluminescence, multispectral VIS-NIR fluorescence, unique direct radioisotopic imaging, and Cerenkov radiation. A high speed digital X-ray scanner with industry-leading resolution and reflectance modes enhance the optical functional images with morphological features.